Drug guidance
Aflibercept, bevacizumab and ramucirumab for treating metastatic colorectal cancer
Condition
Cancer
Gastrointestinal tract
1 June 2026
Published on 01 Apr 2022
Last Updated on 01 Jun 2026
Guidance Recommendations
The Ministry of Health's Drug Advisory Committee has not recommended aflibercept, bevacizumab reference biologic (Avastin) or ramucirumab for subsidy for treating metastatic colorectal cancer.
Bevacizumab (Avastin) has not been recommended in view of unfavourable cost effectiveness compared with bevacizumab biosimilar (Mvasi) at the price proposed by the manufacturer.
Aflibercept has not been recommended due to low clinical need and unfavourable cost effectiveness compared with Mvasi.
Ramucirumab has not been recommended following a request from the manufacturer to not consider it for subsidy.
Clinical indications, subsidy class and MediShield Life claims eligibility for all drugs included in the evaluation are provided in the Annex.
PES Treatments for metastatic colorectal cancer (Updated 19 December 2022) [PDF, 79 KB]