Drug guidance
PARP inhibitors and bevacizumab for treating advanced ovarian cancer
Condition
Cancer
Gynaecological
2 January 2024
Published on 01 Apr 2022
Last Updated on 02 Jan 2024
Guidance Recommendations
The Ministry of Health’s Drug Advisory Committee has recommended:
Olaparib 100 mg and 150 mg tablets; and
Niraparib 100 mg tablet
for treating advanced ovarian cancer in line with specific clinical criteria.
Funding status
Olaparib 100 mg and 150 mg tablets are recommended for inclusion on the Medication Assistance Fund (MAF) with effect from 1 September 2022 for the following indications:
As maintenance monotherapy for adults with advanced BRCA-mutated high-grade epithelial ovarian, fallopian tube or primary peritoneal cancer who are in complete or partial response to first-line platinum-based chemotherapy. Treatment should be continued until disease progression or unacceptable toxicity or for a maximum of 24 months;
In combination with bevacizumab biosimilar (subsidised brand) as maintenance treatment of adults with advanced homologous recombination deficiency (HRD) positive high grade epithelial ovarian, fallopian tube or primary peritoneal cancer who are in complete or partial response to first-line platinum-based chemotherapy in combination with bevacizumab biosimilar. Treatment with olaparib should be continued until disease progression or unacceptable toxicity or for a maximum of 24 months; and
As maintenance monotherapy for patients with platinum-sensitive relapsed BRCA-mutated high-grade epithelial ovarian, fallopian tube or primary peritoneal cancer who are in complete or partial response to platinum-based chemotherapy. Patients must not have received prior treatment with a PARP inhibitor for ovarian cancer. Treatment should be continued until disease progression or unacceptable toxicity.
Niraparib 100 mg tablet is recommended for inclusion on the MAF with effect from 1 March 2024 for the following indication:
As maintenance monotherapy for patients with advanced epithelial high-grade ovarian, fallopian tube or primary peritoneal cancer who are in complete or partial response to first-line platinum-based chemotherapy and whose cancer is associated with BRCA mutation and/or HRD-positive status. Treatment should be continued until disease progression or unacceptable toxicity or for a maximum of 36 months.
Clinical indications, subsidy class and MediShield Life claim limits for all drugs included in the evaluation are provided in the Annex.
PES Treatments for advanced ovarian cancer (Updated 2 Jan 2024) [PDF, 117 KB]