Scientific Publications

ACE publishes key technical evaluations and processes in scientific journals and often presents scientific content at regional and international symposiums and conferences.

Journal Publications

Title	Date of publication
Horizon Scanning To Nominate Subsidy Evaluation Topics For Medical Technologies: Early Experience From Singapore	January 2023
Real-world impact of a subsidy decision of sofosbuvir–velpatasvir for treatment of chronic hepatitis C on clinical practice and patient outcomes	November 2022
Cost-effectiveness of transcatheter aortic valve implantation in patients with severe symptomatic aortic stenosis of intermediate surgical risk in Singapore	August 2022
Real-World Effectiveness and Safety of Non-Vitamin K Antagonist Oral Anticoagulants (NOAC) in Patients with Non-Valvular Atrial Fibrillation (NVAF): A Retrospective Cohort Study in Singapore	July 2022
Real-world evaluation of sodium-glucose co-transporter-2 inhibitors and dipeptidyl peptidase-4 inhibitors for managing type 2 diabetes mellitus: a retrospective multi-ethnic cohort study	March 2022
Cost-effectiveness of daratumumab in combination with lenalidomide and dexamethasone for relapsed and/or refractory multiple myeloma	December 2021
Cost-effectiveness analysis of MRI targeted biopsy strategies for diagnosing prostate cancer in Singapore	September 2021
Cost-effectiveness analysis of the nonavalent human papillomavirus vaccine for the prevention of cervical cancer in Singapore	April 2021
A review of implementation frameworks to operationalize health technology assessment recommendations for medical technologies in the Singapore setting	April 2021
Cost-effectiveness of olaparib maintenance therapy when used with and without restriction by BRCA1/2 mutation status for platinum-sensitive relapsed ovarian cancer	March 2021
Cost-effectiveness of pertuzumab and trastuzumab biosimilar combination therapy as initial treatment for HER2-positive metastatic breast cancer in Singapore	February 2021
Assessing the cost-effectiveness of mepolizumab as add-on therapy to standard of care for severe eosinophilic asthma in Singapore	October 2020
Cost-effectiveness of ribociclib as initial treatment for premenopausal women with advanced breast cancer in Singapore	October 2020
Cost-effectiveness analysis of osimertinib for first line treatment of locally advanced or metastatic EGFR mutation positive non-small cell lung cancer in Singapore	September 2020
Cost utility analysis of tisagenlecleucel vs salvage chemotherapy in the treatment of relapsed/refractory diffuse large B-cell lymphoma from Singapore’s healthcare system perspective	August 2020
Cost-effectiveness analysis of pembrolizumab monotherapy versus chemotherapy for previously untreated advanced non-small cell lung cancer	June 2020
Cost-effectiveness analysis of atezolizumab in advanced triple negative breast cancer	June 2020
Cost-effectiveness of sequential urate lowering therapies for the management of gout in Singapore	May 2020
Towards greater impact in health technology assessment: horizon scanning for new and emerging technologies in Singapore	May 2020
Cost effectiveness analysis of bilateral cochlear implants for children with severe-to-profound sensorineural hearing loss in both ears in Singapore	August 2019
Health technology assessment and its use in drug policies: Singapore	May 2019
Cost-effectiveness analysis of sunitinib versus interferon-alfa for first-line treatment of advanced and/or metastatic renal cell carcinoma in Singapore	March 2019
Comparative efficacy of inhaled medications (ICS/LABA, LAMA, LAMA/LABA and SAMA) for COPD: a systematic review and network meta-analysis	October 2018
Cost effectiveness analysis of afatinib versus pemetrexed-cisplatin for first-line treatment of locally advanced or metastatic EGFR mutation positive non-small-cell lung cancer from the Singapore healthcare payer’s perspective	March 2018
Cost-effectiveness of sacubitril/valsartan versus enalapril in patients with heart failure and reduced ejection fraction	October 2017

Conference Posters

Title	Conference	Date
Funding of treatments for rare diseases in Singapore	17th HTA International Annual Meeting, Beijing, China (Virtual)	June 2020
Meta-Analysis of omalizumab and ciclosporin for chronic spontaneous urticaria	16th HTA International Annual Meeting in Cologne, Germany	June 2019
Comparative efficacy of inhaled medications (ICS/LABA, LAMA, LAMA/LABA and SAMA) in chronic obstructive pulmonary disease: A systematic review and network meta-analysis	8th ISPOR Asia Pacific in Tokyo, Japan	September 2018
Fluorodeoxyglucose positron emission tomography with computerised tomography for oncological indications: a pragmatic approach to guide subsidy decisions	8th ISPOR Asia Pacific in Tokyo, Japan	September 2018
Cost-effectiveness analysis of sunitinib versus interferon-alfa for first-line treatment of advanced and/or metastatic renal cell carcinoma in Singapore	8th ISPOR Asia Pacific in Tokyo, Japan	September 2018
A pilot trial of value-based pricing for medical devices	15th HTA International Annual Meeting in Vancouver, Canada	June 2018
Selection of non-drug medical technologies for evaluation in Singapore	15th HTA International Annual Meeting in Vancouver, Canada	June 2018
Evolution of national drug evaluation processes in Singapore	15th HTA International Annual Meeting in Vancouver, Canada	June 2018